Zootopia is the only movie with no human characters to make $1 billion worldwide in ticket sales.

Zootopia

Total Lifetime Grosses
Domestic:  $341,268,248    33.3%
Foreign:  $682,515,947    66.7%

Worldwide:  $1,023,784,195
Domestic Summary
Opening Weekend:  $75,063,401
(#1 rank, 3,827 theaters, $19,614 average)
% of Total Gross:  22.0%
> View All 22 Weekends
Widest Release:  3,959 theaters
Close Date:  August 4, 2016
In Release:  154 days / 22 weeks

Source: https://www.boxofficemojo.com/movies/?id=disney2016.htm